Capmatinib Hydrochloride Hydrate

Capmatinib Hydrochloride Hydrate (INCB28060) yog lub zog, qhov ncauj, xaiv, ATP kev sib tw c-Met kinase inhibitor (IC50=0.13nM). Kamatinib tuaj yeem cuam tshuam kev loj hlob thiab kev tsiv teb tsaws ntawm c-met raws li cov qog hlwb, thiab tuaj yeem ua rau cov cell apoptosis tau zoo.

Lwm lub npe: Capmatinib hydrochloride; INC 280; IB 028060; INCB-028060; IB 028060; IB 28060; INCB-28060; Capmatinib hydrochloride; 1865733-40-9; Capmatinib 2HCl.H2O; NVP-INC280-AAA; Tabrecta; C2A374O70X; UNII-C2A374O70X; Capmatinib hydrochloride [USAN]; IB 28060; Capmatinib; NVP-INC 280AAA; INC 280; INC -280

Mechanism ntawm kev ua
Capumatinib yog ib qho tsis tshua muaj qhov hnyav molecular uas muaj qhov cuam tshuam rau kev cuam tshuam ntawm mesenchymal epithelial hloov pauv (MET) thiab ntseeg tau tias yuav nthuav tawm cov qog loj hlob inhibitory kev ua si los ntawm inhibiting MET phosphorylation thiab downstream signal transduction.
tau.
kev ua haujlwm antitumor
Capumatinib qhia txog kev ua haujlwm ntawm inhibiting qog kev loj hlob tom qab hloov subcutaneous ntawm cov qog nqaij hlav hauv cov neeg mob ntshav qab zib tsis rog / mob hnyav ua ke nrog kev tiv thaiv kab mob. Cov qog nqaij hlav qog tau muab los ntawm cov neeg mob qog nqaij hlav qog nqaij hlav tsis me me (hauv vivo) raug kev txom nyem los ntawm kev hloov pauv ntawm MET gene exon 14.
qhia
Unreectable lig/recurrent non-small cell lung cancer with MET gene exon 14 jump mutation positive

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