Dab tsi yog qhov cuam tshuam ntawm corosolic acid?

Korosonic acid los ntawm cov extract ntawm Lagerstroemia Indica (feem ntau hu ua Barnanas, muaj ntau nyob hauv tebchaws Philippines). Cov txiaj ntsig ntawm hauv Vitro thiab hauv Vivo kev sim qhia tias kev ua kom haum thiab siv cov roj ntsha los ntawm kev ua kom muaj kev phom sij, yog li ua tiav nws cov txiaj ntsig hypoglycemic. Cov txiaj ntsig zoo siab ntawm cov roj ntsha corosolic tau zoo ib yam li cov tshuaj insulin, yog li ntawd, corosolic acid tseem hu ua tsob ntoo insulin.
1. Corosolic acid, 2 -}}} hydrotolic acid, cov tshuaj ntsuab los ntawm cov accias suav txog cov acid
Hmong npe: coral acid
Lus Askiv Alias: (2VPhaxa, 3xi, 5alpha) -2,3-Dihydroxyurs-12-En-28-oic acid; (2alpha, 3beta) -2,3-Dihyrdoxyurs-12-en-28-oic acid
2. Molecular cov mis: c30h48o4 molecular hnyav 472.7
3 CASE TSIS: 4547-24-4
Tau qhov twg los: rho tawm los ntawm cov paj loj crape crapy myrtle (feem ntau hu ua Npananpas, ntau nyob hauv tebchaws Philippines).
Cov Lus Qhia Tshwj Xeeb: Coronate 2%, Coronate 3%, Coronate 20%, Coronate 30%, Coronate 98% HPLC

Pharmacological cuam tshuam:
Cov txiaj ntsig ntawm hauv Vitro thiab hauv Vivo kev sim qhia tias kev ua kom haum thiab siv cov roj ntsha los ntawm kev ua kom muaj kev phom sij, yog li ua tiav nws cov txiaj ntsig hypoglycemic. Cov txiaj ntsig zoo siab ntawm cov roj ntsha corosolic tau zoo ib yam li cov tshuaj insulin, yog li ntawd, corosolic acid tseem hu ua tsob ntoo insulin. Cov txiaj ntsig ntawm cov kev sim tsiaj pom tias corosonic acid tau cuam tshuam hypoglycemic cuam tshuam rau cov nas thiab muaj txiaj ntsig zoo ntawm cov nas. Korosonic Acid kuj muaj cov teebmeem poob phaus. Cov kev tshawb fawb soj ntsuam pom tau tias kev noj cov tshuaj no tuaj yeem tswj cov tshuaj insulin thiab muaj qhov hnyav poob qis ntawm 0.908- 1.816 kg). Cov txheej txheem yog qeeb thiab tsis xav tau kev noj haus. Korosonic acid kuj muaj ntau lwm cov kev txwv roj ntsha, xws li cov lus teb tseem ceeb tshaj qhov muaj zog tshaj li ntawm cov tshuaj tiv thaiv kev tiv thaiv indomethacin;

Korosolic acid yog hmoov dawb (methanous hmoov (methanol) uas yog soluboform, thiab pyridine hauv dej, thiab soluble hauv cov ethanol thiab methanol. Nyob rau hauv kev mob hnyav, thaum reacting nrog cov muaj zog acids (sulfuric acid, poshloric acid, perchloric acid, perchloric acid), antic acid), cov neeg pleev xim lossis cov fluorescence yuav tshwm sim.

Korosonic acid belongs rau -} aromatic cob cov cawv taub hau lossis Wusane Hom Porteron yog lub penacylic nucleus ntawm polyhydroxypine.

Korosolic acid tuaj yeem muaj nyob hauv cov nroj tsuag lossis hauv daim ntawv ntawm saponins. Hauv cov nroj tsuag, nws feem ntau coexists nrog nws isomer hawthorn acid ({} hydroxicancholics thiab tshuaj lom neeg thiab yog qhov nyuaj cais.

Tam sim no, cov khoom lag luam tau ua lag luam ua kev noj haus kev noj haus hauv Tebchaws Meskas, thiab theem III chaw kuaj mob rau kev kho mob ntshav qab zib tau ua nyob rau tib lub sijhawm. Nws yuav dhau FDA cov ntawv pov thawj nyob ze yav tom ntej. Nws cov txiaj ntsig hauv kev kho ntshav qab zib yog sib piv rau qhov kev txhaj tshuaj insulin, muaj kev cuam tshuam tseem ceeb, kev mob tshuaj lom tsawg tsawg, thiab siv yooj yim. Nws cov txiaj ntsig yog sib piv rau qhov kev txhaj tshuaj insulin.

Korosolic acid, nrog cov tshuaj cultula c30h48o4, yog PentacthClic triterpenoid compound los ntawm crape manrtle. Korosolic acid yog qauv zoo heev li ursolic acid (c30h48o3), nrog tsuas yog ib pab pawg hydroxyl ntxiv ntawm 2 txoj haujlwm.

Corosonic Acid yog ib qho muab rho tawm los ntawm cov nroj tsuag. Cov kev tshawb fawb kho mob qhia tau tias cov tshuaj no tuaj yeem txhim kho cov tsos mob ntawm cov ntshav qab zib rau cov neeg mob ntshav qab zib, thiab tuaj yeem txo cov ntshav qab zib

Korosolic acid yog cov hmoov dawb uas tuaj yeem yaj tag nrho cov etroleum ether thiab benzene, tab sis yog insoluble hauv dej. Nws tuaj yeem yog yaj hauv cov kev daws teeb meem zoo xws li ethanol thiab methanol. Cov neeg ua haujlwm yuav tsum hnav cov khoom tiv thaiv tiv thaiv ua ntej siv. Cov neeg mob feem ntau tuaj yeem txo cov piam thaj hauv ntshav tom qab noj cov ntshav qab zib, txhawb nqa cov tshuaj tsw qab ntawm cov insulin hauv lub cev, thiab tswj cov ntshav qab zib ntawm lub cev. Rau cov neeg siv khoom nrog kev rog, ua raws li txoj kev kho mob tuaj yeem muaj cov txiaj ntsig ntawm kev poob phaus thiab sensuring ntawm tes kev ua si thiab txhawb kev loj hlob ntawm tes thiab kev loj hlob ntawm tes.

Qhov cuam tshuam tseem ceeb ntawm corosolic acid muaj raws li hauv qab no:

1. Nws tuaj yeem tswj cov txheej txheem insulin thiab cov ntshav qab zib hauv lub cev, thiab muaj qhov hnyav hnyav. Cov txheej txheem yog qeeb thiab tsis xav tau kev noj haus. Yog li ntawd, nws tuaj yeem siv rau kev poob phaus.
2. Cov khoom no muaj qhov tseem ceeb hypoglycemic cuam tshuam.
3. Nws muaj qhov tseem ceeb inhibitory nyhuv rau cov txiaj ntsig kev cuam tshuam, thiab nws cov anti- {{tawv muaj cov tshuaj xws li indomethacin.
4. Nws muaj inhibosia teebmeem ntawm kev loj hlob ntawm ntau cov qog ntawm cov qog thiab muaj cov kev cia siab hauv qhov no.